Endocrine Abstracts

Sarcoidosis is a multiorgan disease often affecting the lungs and lymphatic system. Neurological involvement occurs in sarcoidosis as granulomas infiltrate the nervous system. Here, we present a case of neurosarcoidosis diagnosed following non-specific neurological symptoms and delayed hypercalcaemia. A 32-year-old female presents with headaches, vomiting and acute confusion. During admission she developed unresponsive episodes. She has a background of type 1 diabetes and hypo...

Objectives: We aimed to stratify the possible risk factors for diabetic cardiac autonomic neuropathy (CAN).Methods: We did a metaanalysis of risk factors of CAN. We did a web based search for literature in MEDLINE/PubMed, SCOPUS database, and CENTRAL database up to August 2015. We included clinical trials or cohort studies that provide data about relationship between CAN and variables of interest. Our risk factors of interest were age, sex, duration of d...

Introduction: Chemotherapy, as a systemic therapy, is one of the most effective modalities for cancer treatment. However, the use of chemotherapeutic drugs in patients with breast cancer can lead to thyroid dysfunction. The aim of our work is to determine the influence of adjuvant chemotherapy on thyroid function in female patients with breast cancer after radical mastectomy and before radiotherapy.Materials and methods: Our study was conducted on 40 Egy...

Background: Diabetes mellitus (DM) causes damage to many organs and systems. The consequences of diabetes mellitus in the central nervous system are less known than diabetic peripheral neuropathy and autonomic nervous system neuropathy. Damage to the brain and the spinal cord is less common.Aim: The aim of study is to show the importance of motor and somatosensory evoked potentials (MEP and SEP) for early diagnosis of unapparent central nervous system (C...

Purpose: To evaluate long-term safety and efficacy of cinacalcet in management of primary hyperparathyroidism (PHPT).Material/Methods: We retrospectively studied all patients on cinacalcet for primary hyperparathyroidism over 3 year’s period. Data was collected and analyzed for indication, daily maintenance dose, tolerability, biochemical effect at 3, 6 and 12 months, effect on bone mineral density and renal stone disease. This study excluded those ...

Background: The treatment goal in primary hyperparathyroidism (PHPT) is the achievement of biochemical control and prevention of target organ complications. Parathyroidectomy is the current recommended intervention to cure the disease. However, Cinacalcet is an alternative medical treatment for subgroup of patients in whom surgery is deemed inappropriate, those with recurrent disease, and as bridging therapy for delayed operation particularly in recent COVID pandemic. Current ...

Introduction: Thyroid hormone resistance due to a TRα mutation is rare and only recently described. We report a case of primary hyperparathyroidism in an adult patient with a known TRα mutation.Case presentation: A 60 year old female was referred with hypercalcaemia and hyperparathyroidism that persisted despite correction of vitamin D deficiency. Parathyroid hormone levels continued to be elevated or inappropriately normal with hyper- or normo...

Prompt, effective and safe management of Diabetic Ketoacidosis (DKA) is key to reducing mortality rate and length of stay. An Integrated care pathway (ICP) Pro-forma for DKA management during the first 24 hrs, based on a modified JBDS guideline was introduced in the trust. DKA management based on the pro-forma between Nov 17 to Feb 18 was audited; focussing on fluid management in terms of timing and electrolyte replacement, CBG monitoring, faster senior reviews, HDU admissions...

The purpose of this prospective cohort study was to evaluate whether early insulin therapy is more advantageous in achieving long-term optimal glycemic control with improved B cell function than oral drugs in the recently diagnosed type 2 diabetes mellitus. Methods: Sixty consecutive patients with recently diagnosed type 2 diabetes mellitus were divided into 3 groups.The 1st group received 2 SC injections of premixed insulin. The 2nd group received bed time NPH and 3 injection...

Introduction: Lower limb amputation is associated with high morbidity and mortality. As a middle-income country, we are particularly vulnerable to diabetes-related problems. The aim of this study is to identify significant risk factors for amputations.Materials and methods: This is a prospective descriptive study conducted from June 2020 to June 2022 on 102 patients hospitalized for diabetic foot at the Endocrinology-Diabetology Department of Oran Univer...